منابع مشابه
Matrix Gla protein in tumoral pathology
Matrix Gla protein is a vitamin K-dependent protein secreted by chondrocytes and vascular smooth muscle cells. The presence of matrix Gla protein was reported in arterial and venous walls, lungs, kidney, uterus, heart, tooth cementum and eyes. Several studies identified matrix Gla protein in tumoral pathology. Until recently, it was thought to only have an inhibitory role of physiological and e...
متن کاملCirculating matrix Gla protein in patients with vascular pathology
competitive ELISA for desphosphorylated MGP (dpMGP) (Braam et al 2000) and uncarboxylated MGP (ucMGP) (Schurgers et al 2005a) and also sandwich-ELISA for desphosphorylatedcarboxylated MGP (dp-cMGP) or desphosphorylated-uncarboxylated MGP (dp-ucMGP) (Schurgers et al 2010). Several studies were established an association of these conformations with VD: low serum ucMGP was considered a potential i...
متن کاملEvaluation of gene expression pattern of matrix gla protein and Bone gla protein as skeletogenesis markers in Persian sturgeon (Acipenser persicus Bordin, 1897)
Bone gla protein and matrix gla protein are of common origin with evolutionary relation and have similar structural features and are functional in the formation of skeletal structures The present study have been evaluated the genes encoding vitamin k-dependant proteins (VKDPs) expression at hatching time (0), 1, 3, 6, 10, 12,14, 20, 30 and 50 in skeletal Persian sturgeon sturgeon (Acipenser per...
متن کاملMatrix Gla protein reinforces angiogenic resolution.
Matrix Gla Protein (MGP) is an ECM molecule commonly associated with dysfunctions of large blood vessels such as arteriosclerosis and atherosclerosis. However, the exact role of MGP in the microvasculature is not clear. Utilizing a mouse MGP knockout model we found that MGP suppresses angiogenic sprouting from mouse aorta restricts microvascular density in cardiac and skeletal muscle, and is an...
متن کاملNovel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification.
OBJECTIVE Matrix gamma-carboxyglutamic acid (Gla) protein (MGP), a vitamin K-dependent protein, is a potent in vivo inhibitor of arterial calcification. We hypothesized that low endogenous production of MGP and impaired carboxylation of MGP may contribute to the development or the progression of vascular disease. METHODS AND RESULTS Novel conformation-specific antibodies against MGP were used...
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ژورنال
عنوان ژورنال: Medicine and Pharmacy Reports
سال: 2016
ISSN: 2668-0572,2602-0807
DOI: 10.15386/cjmed-579